THE ATLANTA CLASSIFICATION AND DEFINITIONS OF ACUTE PANCREATITIS HAVE BEEN REVISED AND ARE BASED ON WORLDWIDE CONSENSUS.
DOI:
https://doi.org/10.64516/1aqfbq36Keywords:
Acute pancreatitis, Predictive severity scoring system, The Atlanta definitions, CECT imaging, Multi-organ failure, Necrosectomy, Pancreatic necrosisAbstract
Background and Objective: In a complex disease such as acute pancreatitis, correct terminology and clear definitions are important. The clinically based Atlanta Classification was formulated in 1992, but in recent years it has been increasingly criticized. No formal evaluation of the use of the Atlanta definitions in the literature has ever been performed. Deficiencies identified and improved understanding of the disease make a revision necessary.
Methods: A Medline literature search sought studies published after 1993. The guidelines, review articles, and their cross-references were reviewed to assess whether the Atlanta or alternative definitions were used. Revisions were made in response to comments. The consensus was reviewed, and only statements based on published evidence were retained.
Results: The severity of the disease is classified as mild, moderate, or severe. Mild acute pancreatitis, the most common form, has no organ failure, local or systemic complications, and usually resolves in the first week. Moderately severe acute pancreatitis is defined by the presence of transient organ failure, local complications, or exacerbation of co-morbid disease. Severe acute pancreatitis is defined by persistent organ failure, that is, organ failure lasting more than 48 h. Local complications are peripancreatic fluid collections, pancreatic and peripancreatic necrosis (sterile or infected), pseudocysts, and walled-off necrosis (sterile or infected). We present a standardized template for reporting CT images. There was a large variation in the interpretation of the Atlanta definitions of local complications, especially relating to the content of peripancreatic collections.
Conclusion: The Atlanta definitions for acute pancreatitis are often used inappropriately, and alternative definitions are frequently applied. Such a lack of consensus illustrates the need for a revision of the Atlanta Classification. So, the consensus provides clear definitions to classify acute pancreatitis using easily identified clinical and radiological criteria.
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References
1-Sarles H. Proposal adopted unanimously by the participants of the Symposium, Marseille 1963. Bibl Gastroenterol 1965; 7: 7–8.
2-Sarner M, Cotton PB. Classification of pancreatitis. Gut
3- 1984; 25: 756 – 759.
4-Singer MV, Gyr K, Sarles H. Revised classification of pancreatitis. Report of the Second
International Symposium on the Classification of Pancreatitis in Marseille, France, March 28–30,
1984. Gastroenterology 1985; 89: 683–685. 5-BradleyELIII.Aclinicallybasedclassificationsystemfor acute pancreatitis. Summary of the DOI: https://doi.org/10.1016/0016-5085(85)90468-8
International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992.
ArchSurg1993;128:586–590.
6-BradleyELIII.Aclinicallybasedclassificationsystemfor acutepancreatitis.Ann Chir 1993;
47: 537–541.
7-Banks PA, Freeman ML, the Practice Parameters CommitteeoftheAmericanCollegeof
Gastroenterology (2006). Practice guidelines in acute pancreatitis. Am J Gastroenterol
2006; 101: 2379–2400.
8-Baron TH, Morgan DE, Vickers SM, Lazenby AJ. Organized pancreatic necrosis: endoscopic,
radiologic, and pathologic features of a distinct clinical entity. Pancreas 1999; 19: 105–108. DOI: https://doi.org/10.1097/00006676-199907000-00016
9-Besselink MG, van Santvoort HC, Bollen TL, van Leeuwen MS, Lameris JS, van der Jagt EJ et al. Describing computed tomography findings in acute necrotizing pancreatitis with the Atlantaclassification:aninterobserver agreementstudy.Pancreas 2006;33:331–335. DOI: https://doi.org/10.1097/01.mpa.0000240598.88193.8e
10- DervenisC,BassiC.Evidence-basedassessmentofseverityandmanagementofacutepancreatitis. Br J Surg 2000; 87: 257 – 258.
11- MorganDE,BaronTH,SmithJK,RobbinML,
12- Kenney PJ. Pancreatic fluid collections prior to intervention: evaluation with MR imaging
compared with CT and US. Radiology 1997; 203: 773 – 778. DOI: https://doi.org/10.1148/radiology.203.3.9169703
13- PapachristouGI,PapachristouDJ,AvulaH,SlivkaA, WhitcombDC.Obesityincreasesthe
severity of acute pancreatitis: performance of APACHE-O score and correlation with the
inflammatory response. Pancreatology 2006; 6: 279–285. DOI: https://doi.org/10.1159/000092689
14- PetrakisI,VrachassotakisN,KogerakisN,KoutsoumpasV, ChalkiadakisG.Subacutepancreatic
necrosis. Panminerva Med 2000; 42: 279–286. DOI: https://doi.org/10.1111/j.1469-8749.2000.tb00088.x
15- VegeSS,ChariST.Organfailureasanindicatorofseverity of acute pancreatitis: time to revisit
the Atlanta classification.Gastroenterology 2005;128:1133–1135. DOI: https://doi.org/10.1053/j.gastro.2005.02.059
16- BollenTL,BesselinkMG,VanSantvoortHC,
17- GooszenHG,VanLeeuwenMS.TowardsanupdateoftheAtlantaclassificationonacute
pancreatitis:reviewofnew andabandonedterms.Pancreas 2007;35:107–113. DOI: https://doi.org/10.1097/mpa.0b013e31804fa189
18- AcostaJM,KatkhoudaN,DebianKA,GroshenSG, Tsao-WeiDD,BerneTV.Earlyductal
decompression versus conservative management for gallstone pancreatitis with ampullary
obstruction:aprospectiverandomized clinical trial. Ann Surg 2006; 243: 33–40. DOI: https://doi.org/10.1097/01.sla.0000194086.22580.92
19- GargPK,MadanK,PandeGK,KhannaS,SathyanarayanG,BohidarNPetal.Associationof
extent and infection of pancreatic necrosis with organ failure and death in acute necrotizing
pancreatitis. Clin Gastroenterol Hepatol 2005; 3: 159–166.
20- HofnerP,BalogA,GyulaiZ,FarkasG,RakonczayZ, TakacsTetal.Polymorphisminthe
IL-8gene,butnotin theTLR4gene,increasestheseverityofacutepancreatitis. Pancreatology
2006; 6: 542–548.
21- McKayCJ,CurranF,SharplesC,BaxterJN,ImrieCW. Prospective placebo-controlled
randomized trial of lexipafant in predicted severe acute pancreatitis. Br J Surg 1997; 84: 1239– DOI: https://doi.org/10.1046/j.1365-2168.1997.00512.x
1243.
22- MeryCM,RubioV,Duarte-RojoA,Suazo-BarahonaJ, Pelaez-LunaM,MilkePetal.Android
fatdistributionas predictorofseverityinacutepancreatitis.Pancreatology 2002; 2: 543–549. DOI: https://doi.org/10.1159/000066099
23- MurrayB,CarterR,ImrieC,EvansS,O’SuilleabhainC.Diclofenacreducestheincidenceofacute
pancreatitis after endoscopic retrograde cholangiopancreatography. Gastroenterology 2003;
124: 1786–1791.
24- MasciE,CavalliniG,MarianiA,FrulloniL,TestoniPA, CurioniSet al.Comparisonoftwo
dosingregimensof gabexateintheprophylaxisofpost-ERCPpancreatitis.Am J Gastroenterol
2003; 98: 2182–2186.
25- Rahman SH, Ibrahim K, Larvin M, Kingsnorth A, McMahonMJ.Associationof
antioxidant enzyme gene polymorphisms and glutathione status with severe acute pancreatitis.
Gastroenterology 2004; 126: 1312–1322. DOI: https://doi.org/10.1053/j.gastro.2004.02.002
26- Remes-TrocheJM,UscangaLF,Pelaez-LunaM,
27- Duarte-RojoA,Gonzalez-BalboaP,TelizMAetal.When shouldwebeconcernedabout
pancreatic necrosis? Analysis from a single institution in Mexico City. World J Surg 2006; 28- 30: 2227 – 2233 DOI: https://doi.org/10.1007/s00268-006-0148-8
28- MartinezJ,JohnsonCD,Sanchez-PayaJ,deMadariaE, Robles-DiazG,Perez-MateoM. Obesityisadefinitiverisk factorofseverityandmortalityinacutepancreatitis:an updatedmeta- analysis. Pancreatology 2006; 6: 206–209. DOI: https://doi.org/10.1159/000092104
29- StimacD,FisicE,MilicS,Bilic-ZulleL,PericR. PrognosticvaluesofIL-6,IL-8,and IL-10inacute pancreatitis.JClinGastroenterol2006;40:209–212. DOI: https://doi.org/10.1097/00004836-200603000-00007
30- BalthazarEJ,RobinsonDL,MegibowAJ,RansonJH.Acutepancreatitis:valueofCTin establishing prognosis. Radiology 1990; 174: 331–336. DOI: https://doi.org/10.1148/radiology.174.2.2296641
31- JuS,ChenF,LiuS,ZhengK,TengG.ValueofCTand clinicalcriteriainassessmentof patientswithacute pancreatitis.EurJRadiol2006;57:102–107.
32- KumarA,SinghN,PrakashS,SarayaA,JoshiYK.Early enteralnutritioninsevereacute pancreatitis:aprospective randomizedcontrolledtrialcomparingnasojejunaland nasogastric routes. J Clin Gastroenterol 2006; 40: 431–434. DOI: https://doi.org/10.1097/00004836-200605000-00013
33- LeungTK,LeeCM,LinSY,ChenHC,WangHJ,
34- ShenLKetal.BalthazarcomputedtomographyseverityindexissuperiortoRansoncriteriaand
APACHE II scoring system in predicting acute pancreatitis outcome. World J Gastroenterol
2005; 11: 6049–6052.
35- ModrauIS,FloydAK,Thorlacius-UssingO.Theclinical value of procalcitonin in early
assessment of acute pancreatitis. Am J Gastroenterol 2005; 100: 1593–1597. DOI: https://doi.org/10.1111/j.1572-0241.2005.41456.x
36- MofidiR,DuffMD,WigmoreSJ,MadhavanKK,
37- Garden OJ, Parks RW. Association between early systemic inflammatory response, severity of
multiorgan dysfunction and death in acute pancreatitis. Br J Surg 2006; 93: 738 – 744. DOI: https://doi.org/10.1002/bjs.5290
38- Taylor SL, Morgan DL, Denson KD, Lane MM, PenningtonLR.Acomparisonofthe
Ranson,Glasgow,and APACHEIIscoringsystemstoamultipleorgansystem scorein
predictingpatientoutcomeinpancreatitis.AmJ Surg 2005;189:219–222.
39- NealonWH,BawduniakJ,WalserEM.Appropriatetimingofcholecystectomyinpatientswho
present with moderate to severe gallstone-associated acute pancreatitis with peripancreatic fluid
collections. Ann Surg 2004; 239: 741–749. DOI: https://doi.org/10.1097/01.sla.0000128688.97556.94
40- Runzi M, Niebel W, Goebell H, Gerken G, Layer P. Severeacutepancreatitis:nonsurgical
treatmentofinfected necroses. Pancreas 2005; 30: 195–199. DOI: https://doi.org/10.1097/01.mpa.0000153613.17643.b3
41- Toouli J, Brooke-Smith M, Bassi C, Carr-Locke D, Telford J, Freeny P et al. Guidelines for
the management of acute pancreatitis. J Gastroenterol Hepatol 2002; 17(Suppl): S15 – S39.
42- FrenchConsensusConferenceonAcutePancreatitis: ConclusionsandRecommendations.
Paris,France,25–26 January2001.Eur J Gastroenterol Hepatol 2001;13(Suppl4): S1–S13.
43- MartinezJ,Sanchez-PayaJ,PalazonJM,AparicioJR,PicoA,Perez-MateoM.Obesity:a
prognostic factor of severity in acute pancreatitis. Pancreas 1999; 19: 15–20. DOI: https://doi.org/10.1097/00006676-199907000-00002
44- HellerSJ,NoordhoekE,TennerSM,RamagopalV, AbramowitzM,HughesMet al. Pleural effusion as a predictor of severity in acute pancreatitis. Pancreas 1997; 15: 222 – 225. DOI: https://doi.org/10.1097/00006676-199710000-00002
45- TalaminiG,BassiC,FalconiM,SartoriN,FrulloniL,DiFrancescoVetal.Riskofdeathfrom acutepancreatitis. Roleofearly,simple‘routine’data.Int J Pancreatol 1996; 19: 15–24. DOI: https://doi.org/10.1007/BF02788371
46- TalaminiG,UomoG,PezzilliR,RabittiPG,BilliP,
47- BassiCetal.Serumcreatinineandchestradiographsintheearlyassessmentofacutepancreatitis.Am
JSurg1999;177: 7–14.
48- BrownA,OravJ,BanksPA.Hemoconcentrationisanearly markerfororganfailureand
necrotizingpancreatitis. Pancreas 2000; 20: 367–372. DOI: https://doi.org/10.1097/00006676-200005000-00005
49- BrownA,BaillargeonJD,HughesMD,BanksPA.Canfluidresuscitationpreventpancreatic
necrosis in severe acute pancreatitis? Pancreatology 2002; 2: 104–107. DOI: https://doi.org/10.1159/000055899
50- UK Working Party on Acute Pancreatitis. UK guidelines for the management of acute
pancreatitis. Gut 2005; 54(Suppl 3): iii1 – iii9. DOI: https://doi.org/10.1136/gut.2004.057026
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