Comparative Evaluation of Aspirin Purity Using Titration, Infrared (IR), and Nuclear Magnetic Resonance (NMR) Spectroscopy: A Multi-Technique Quality Control Study

Saadeldin Elamin  Taher; Moftah  Moustafa

doi:10.64516/sn3j4z34

Authors

Saadeldin Elamin Taher Tobruk University, Libya Author
Moftah A. Moustafa Tobruk University, Libya Author

DOI:

https://doi.org/10.64516/sn3j4z34

Keywords:

Aspirin Purity, Titration , Infrared , Nuclear Magnetic Resonance (NMR) Spectroscopy

Abstract

The stability and chemical purity of over-the-counter drugs are a worldwide public health issue. This article presents a comparative multi-modal assessment of Egyptian (M), Turkish (B), and British (H) over-the-counter commercial acetylsalicylic acid (aspirin). Three analytical methods were applied to ninety-three samples: acid-base titration with three concentrations of NaOH (0.1 M, 0.2 M, 0.5 M), Fourier-transform infrared (FTIR) spectroscopy, and proton nuclear magnetic resonance (1H-NMR) spectroscopy. Producer H had the highest mean purity and structural integrity, followed by B and M. FTIR confirmed functional group integrity, and 1H-NMR effectively marked degradation products. The combination of traditional and spectroscopic methods highlights the importance of orthogonal analytical approaches in both pharmaceutical quality control and regulatory needs.

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Author Biographies

Saadeldin Elamin Taher, Tobruk University, Libya

Chemistry Department, Faculty of Science, Tobruk University, Libya
Moftah A. Moustafa, Tobruk University, Libya

Chemistry Department, Faculty of Science, Tobruk University, Libya

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